If the man in your life needs to lose weight, hereâ??s more motivation to help him cut out junk food and hit the gym!
At the time of biopsy, obese men had a 57% increased incidence of prostate cancer during follow-up, according to researchers at Columbia University’s Mailman School of Public Health.
Obese men were more likely to have precancerous lesions detected in their benign prostate biopsies compared with men who have a healthy body weight, and were at a greater risk of developing prostate cancer.
“Our study is focused on a large group of men who have had a prostate biopsy that is benign but are still at a very high risk for prostate cancer,” says Andrew Rundle, DrPH, Associate Professor of Epidemiology and the first author of the paper.
“Studies conducted in the past have attempted to determine if there are subpopulations of men diagnosed with benign conditions that may be at a greater risk for developing prostate cancer. Here we were able to show that obesity is associated with a significantly higher risk of prostate cancer after an initial benign biopsy, particularly in the first few years after a biopsy,â? says Dr Rundle. â??This was also one of the first studies to assess the association between obesity and precancerous abnormalities in the benign biopsy tissue specimens.”
Dr Rundle and his colleagues investigated the association between obesity and future prostate cancer incidence within 6 692 men at the Henry Ford Health System who were followed for 14 years after a biopsy or transurethral resection of the prostate with benign findings.
After accounting for variables including family history of prostate cancer, prostate-specific antigen (PSA) levels during the initial procedure, and the number of PSA tests and digital rectal exams during follow-up, the researchers found that obesity at the time of the initial procedure was associated with a 57% increased incidence of prostate cancer during follow-up.
These findings were published online in Cancer Epidemiology, Biomarkers & Prevention, an American Association for Cancer Research journal.
“We don’t absolutely know what the true biology is,” said Dr Rundle “In some ways, this reflects the association between the body size and larger prostate size, which is thought to reduce the sensitivity of the needle biopsy. It is possible that the tumours missed by initial biopsy grew and were detected in a follow-up biopsy.”
For more information on prostate cancer, read Deep-fried food linked to prostate cancer
Source: Columbia University’s Mailman School of Public Health via Eureka Alert
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