“A petrol tanker lost control heading down the N12 near Voortrekker Road in Alberton,” ER24 spokesman Russel Meiring said. “He collided with multiple vehicles. ER24 as well as other medical services have begun treating the injured.

According to Arrive Aliveâ??s Twitter feed, approximately forty-five vehicles and two heavy goods vehicles were involved in the accident. Witnesses said some of the vehicles nearly caught fire, â??it was horrific.â?

Netcare911 spokesman Santi Steinmann said two critically injured patients were airlifted to hospital. Another two commuters have been confirmed dead, and at least 50 sustained injuries.

It was believed the accident happened around 7.30am.

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Ekurhuleni metro police were not immediately available for comment.